Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN12 All Species: 12.42
Human Site: T718 Identified Species: 27.33
UniProt: Q05209 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q05209 NP_001124480.1 780 88120 T718 K K S E G L I T S E N E K C D
Chimpanzee Pan troglodytes XP_519168 792 88529 T730 K K S E G L I T S E N E K C D
Rhesus Macaque Macaca mulatta XP_001082837 733 82786 P676 V S E D S P P P L P E R T P E
Dog Lupus familis XP_540396 757 85032 T695 K I P E G L I T P G S E K C D
Cat Felis silvestris
Mouse Mus musculus P35831 775 86973 N718 E G L T T S G N E K H D A G G
Rat Rattus norvegicus NP_476456 766 85965 T709 R E S E G L I T S G N D K H D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507461 747 83881 G689 C E Q K K S E G L F S S Q E R
Chicken Gallus gallus XP_415970 1211 131521 T1139 D Q H L P E Q T V Y T G L K A
Frog Xenopus laevis NP_001084841 660 74123 A603 S L L N I S T A S A T V S A A
Zebra Danio Brachydanio rerio NP_956963 570 64484 A513 S E E Q P A G A A D T A P L Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796904 967 106580 A769 V D T S K I V A P E K P K R G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.5 91.4 88 N.A. 82.8 83.5 N.A. 74.6 48.3 58.2 46.7 N.A. N.A. N.A. N.A. 28.9
Protein Similarity: 100 95.4 92.3 91 N.A. 88.3 88.8 N.A. 81.1 53.5 66.9 57.4 N.A. N.A. N.A. N.A. 44
P-Site Identity: 100 100 0 66.6 N.A. 0 66.6 N.A. 0 6.6 6.6 0 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 13.3 73.3 N.A. 26.6 86.6 N.A. 26.6 13.3 6.6 26.6 N.A. N.A. N.A. N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 0 28 10 10 0 10 10 10 19 % A
% Cys: 10 0 0 0 0 0 0 0 0 0 0 0 0 28 0 % C
% Asp: 10 10 0 10 0 0 0 0 0 10 0 19 0 0 37 % D
% Glu: 10 28 19 37 0 10 10 0 10 28 10 28 0 10 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % F
% Gly: 0 10 0 0 37 0 19 10 0 19 0 10 0 10 19 % G
% His: 0 0 10 0 0 0 0 0 0 0 10 0 0 10 0 % H
% Ile: 0 10 0 0 10 10 37 0 0 0 0 0 0 0 0 % I
% Lys: 28 19 0 10 19 0 0 0 0 10 10 0 46 10 0 % K
% Leu: 0 10 19 10 0 37 0 0 19 0 0 0 10 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 10 0 0 0 10 0 0 28 0 0 0 0 % N
% Pro: 0 0 10 0 19 10 10 10 19 10 0 10 10 10 0 % P
% Gln: 0 10 10 10 0 0 10 0 0 0 0 0 10 0 10 % Q
% Arg: 10 0 0 0 0 0 0 0 0 0 0 10 0 10 10 % R
% Ser: 19 10 28 10 10 28 0 0 37 0 19 10 10 0 0 % S
% Thr: 0 0 10 10 10 0 10 46 0 0 28 0 10 0 0 % T
% Val: 19 0 0 0 0 0 10 0 10 0 0 10 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _